Comprehensive Chromosome Screening (CCS)

CCS Improves Embryo Implantation & Live Birth Rates

We are excited to inform you that all of our IVF clinics now offer Comprehensive Chromosome Screening (CCS). This type of screening is highly recommended for those of advanced maternal age (AMA), as well as to patients who have had multiple failed IVF cycles or numerous miscarriages.

Incidentally, did you know that our all inclusive IVF packages start at $8,199 and include airfare for two and hotel stay?

In order to increase the probability of achieving a pregnancy, most IVF clinics transfer more than one embryo per cycle. This approach increases patient’s likelihood of becoming pregnant, but also leads to an elevated risk of multiple gestation (e.g. twins). Moreover, studies show that nearly 60% of all early miscarriages are attributed to some sort of chromosomal abnormality, aneuploidy, in the fetus. Until recently, reproductive endocrinologists utilized PGD to identify aneuploid embryos. Although PGD is a very sophisticated test and improves pregnancy outcomes for properly selected patients, this test has major limitations. Recent advances in the field of fertility gave birth to a new type of embryo screening called Comprehensive Chromosome Screening or CCS. This ground-breaking IVF technique is utmost accurate method for the simultaneous analysis of all 24 types of chromosome. Although this technique is still relatively experimental and undergoing clinical trials, the few IVF clinics which are running these trials are seeing major improvements in implantation success rates and live birth rates.

PGD and Its Limitations

Comprehensive_Chromosome_ScreeningA large number of unsuccessful IVF cycles can be attributed to the presence of numerical chromosomal abnormalities. Embryos derived from aneuploid or defective gametes stand little chance of forming a viable pregnancy. Consequently, screening of oocytes or embryos for chromosome abnormalities prior to embryo transfer (ET) can greatly improve pregnancy rates, decrease miscarriage rates, as well as reduce the risk of having a child with syndromes such as Down or Turner. For over a decade, IVF clinics have relied on the Preimplantation Genetic Diagnosis test to identify aneuploid embryos. However, PGD testing, which is based on a one-cell biopsy followed by fluorescent in situ hybridization (FISH), allows less than half of the chromosomes to be screened. The recently developed Comparative Genomic Hybridization (CGH) method allows to overcome the limitations of PGD.

How CCS Works and Its Advantages

Although embryo screening using above mentioned FISH methods may lead to improved outcomes for some IVF patients, PGD testing does have some significant limitations. PGD does not allow screening of all 24 types of chromosomes and does not detect chromosome breakage. Recent CGH studies reveal fascinating findings. For instance, between twenty and forty percent of all embryos carry chromosome abnormalities that could not be detected using FISH screens employed in conventional PGD. These chromosome abnormalities in human embryos can cause developmental arrest during the preimplantation phase, implantation failure and/or miscarriage.

CCS allows our RE’s and geneticists to identify the most viable euploid embryos. The process, however, is rather complex. Ideally, and depending on the quality of developing embryos, IVF doctors prefer to transfer fresh embryos, once those reach blastocyst stage. This happens on day five of embryo development. Furthermore, day 5 blastocysts allow a window of only six hours to perform any analysis of fresh embryos.

IVF_Comprehensive_Chromosome_ScreeningTo perform a PGD, embryologist removes a single cell from an embryo in day 3 cleavage stage of embryo development. In case of CCS, the embryologists must obtain more than one cell for genetic analysis. This is possible only in later blastocyst stage.

Difficulties arise when geneticists have to perform cell analysis which takes longer than six hours to complete. To overcome this problem, embryologists put blastocysts into a state of suspended development until genetic lab results become available. This is done by way of Vitrification, the rapid freezing and cryopreservation technique recently developed in Japan.

Incidentally, waiting for lab results allows patient’s body to return to a more normal state after ovarian stimulation. Research shows that transfer of embryos into the uterus of patients in a more natural hormonal state further increases chances of implantation. The IVF process is completed once our fertility doctors receive the results of the Comprehensive Chromosomal Screening and transfer embryos free of genetic defects.

Our fertility clinic was one of the first IVF clinics in the world to offer this ground breaking technology. The cost of adding Comprehensive Chromosomal Screening with biopsy to your IVF package is $3,999.

Call us today for a free consultation with a fertility doctor and our affordable IVF package details or click below to get started.

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